PharMab, Inc., located in Zhangjiang HighTech Park of Pudong, Shanghai, China
PharMab positions itself as the leading company in China in developing biopharmaceuticals using genetic engineering techniques. Equipped with the most advanced instruments and laboratory facility, the company has established a unique technology platform stemming from numerous years of experience of its technical team in research and development of biotech products. This technology platform could streamline the production and development of therapeutic monoclonal antibody products and their derivatives.
Biotechnology will become the premier industry in the 21st century. It will be the focal point of global race in technology and economy. The bio-economy, as it builds around the biotech industry, will play the leading role in the growth of global economy in many years to come. The goal of PharMab is to become a leader China in the development of proprietary biotech products using its unique technology platform, and to compete in the international market, as China is elevating its presence and strengthen its competitiveness in the global biotech community.
Technology Platform
1. Antibody Technology Platform
With its unique and powerful techniques in immunization, fusion, and functional screening, PharMab is able to effectively develop monoclonal antibodies with high specificity and affinity against desired disease target molecules. It could subsequently humanize the antibody candidates for therapeutic development.
2. Protein Expression and Purification Platform
With its unique protein expression techniques, PharMab is able to create cell lines derived from mammalian host cells, including Chinese Hamster Ovary (CHO) and murine myeloma cells, to express the target genes at high secretion levels. Paired with its proprietary medium formulation and cell culture techniques, PharMab is also able to grow these cells in suspension culture to produce high levels of protein (including monoclonal antibody) products. In addition, PharMab also has the capability to purify these protein products to high degree of purity using chromatographic methods.
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1. 熟悉ELISA 检测和细胞水平生物活性检测的方法和原理，可对分析方法进行开发、优化、方法学验证和样本分析。
2. 熟悉细胞水平生物活性检测的方法，具有一定的细胞培养经验，可对分析方法进行开发、优化、方法学验证和样本分析；
3. 负责实验室仪器的使用和维护，发现、分析并解决技术问题、项目难点等；
4. 具有高度的责任感，能坚持原则，确保所有工作流程符合法规及部门SOP要求，主动向项目主管汇报；
5. 负责及时记录研究中发生的任何偏离试验方案或SOP的情况，并做相关的汇总
6. 较强的主动学习能力，对生物分析领域里的新仪器 (如 MSD) 可进行自我培训、寻求问题解决方案
7. 较好的英文文献阅读和书写能力；
8. 良好的道德品质，工作细致负责，有耐心、踏实勤奋
